Though more difficult settings will be accessible, start it off easy. Even experienced pros who can perform All-Madden difficulty with one hand tied behind their backs will come across the toughest assignments too hard to finish with a reasonable success rate.
By completing easy assignments, rewards will be allowed that assist with the tougher ones. So start low to get a solid foundation, then move up as cards and strategies enhance and synergize together. It can be tempting to dive right into the weeds and begin buying cards in the community or looking at packs to buy. However, there are predatory practices for auctions that aim impatient players that want to play head-to-head right away.